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81.
Anna Rita Bavaro Mariaelena Di Biase Amalia Conte Stella Lisa Lonigro Leonardo Caputo Annamaria Cedola Matteo Alessandro Del Nobile Antonio Francesco Logrieco Paola Lavermicocca Francesca Valerio 《International Journal of Food Science & Technology》2021,56(7):3197-3208
Production of the traditional Italian Focaccia bread (FcBread) requires reformulation to meet the new rules for healthier foods. We tested the applicability of a short-fermented (15 h) liquid sourdough (LS) (dough yield, DY, 250), obtained using quinoa (Q) or amaranth (Am) flour fermented with a Weissella cibaria strain (C43-11) producing exopolysaccharides (EPS) as fat replacer in yeast-leavened FcBread. The LSs were applied during the FcBread-making process at industrial pilot plant, reducing the added fat amount by 20% (FcBread-QLS and FcBread-AmLS) and products were compared with reference samples not containing EPS. All the products were analysed for physico-chemical properties (pH, TTA, organic acids, protein content and profile, instrumental colour), textural properties, sensory quality and glycemic index. The application of both pseudo-cereal-based W. cibaria LSs in FcBread allowed obtaining products with a reduced amount of fat, increased protein amount, mainly due to the albumin and glutenin/glutelin fractions, reduced glycemic index, improved texture and preserved in the traditional sensory profile of ‘focaccia’. 相似文献
82.
Jessica Mendes Nadal Mona Lisa Simionatto Gomes Débora Maria Borsato Martinha Antunes Almeida Fernanda Malaquias Barboza Sônia Faria Zawadzki 《Drug development and industrial pharmacy》2016,42(11):1813-1824
This article aimed to improve the relative solubility and dissolution rate of ferulic acid (FA) by the use of spray-dried solid dispersions (SDs) in order to ensure its in vitro antioxidant potential and to enhance its in vivo anti-platelet effect. These SDs were prepared by spray-drying at 10 and 20% of drug concentration using polyvinylpyrrolidone K30 (PVP-K30), polyethylene glycol 6000 (PEG 6000) and poloxamer-188 (PLX-188) as carriers. SDs and physical mixtures (PM) were characterized by SEM, XRPD, FTIR spectroscopy and TGA analysis. Spray-dried SDs containing FA were successfully obtained. Relative solubility of FA was improved with increasing carrier concentration. PVP-K30 and PEG 6000 formulations showed suitable drug content values close to 100%, whereas PLX-188 presented mean values between 70 and 90%. Agglomerates were observed depending on the carrier used. XRPD patterns and thermograms indicated that spray-drying led to drug amorphization and provided appropriate thermal stability, respectively. FTIR spectra demonstrated no remarkable interaction between carrier and drug for PEG 6000 and PLX-188 SDs. PVP-K30 formulations had changes in FTIR spectra, which denoted intermolecular O–H???O?=?C bonds. Spray-dried SDs played an important role in enhancing dissolution rate of FA when compared to pure drug. The free radical-scavenging assay confirmed that the antioxidant activity of PEG 6000 10% SDs was kept. This formulation also provided a statistically increased in vivo anti-platelet effect compared to pure drug. In summary, these formulations enhanced relative solubility and dissolution rate of FA and chosen formulation demonstrated suitable in vitro antioxidant activity and improved in vivo anti-platelet effect. 相似文献
83.
Giuseppe Ateniese Alfredo De Santis Anna Lisa Ferrara Barbara Masucci 《Journal of Cryptology》2012,25(2):243-270
A time-bound hierarchical key assignment scheme is a method to assign time-dependent encryption keys to a set of classes in a partially ordered hierarchy, in such a way
that each class can compute the keys of all classes lower down in the hierarchy, according to temporal constraints. 相似文献
84.
85.
Karina Pombo García Kristof Zarschler Lisa Barbaro José A. Barreto William O'Malley Leone Spiccia Holger Stephan Bim Graham 《Small (Weinheim an der Bergstrasse, Germany)》2014,10(13):2516-2529
Nanoparticles represent highly promising platforms for the development of imaging and therapeutic agents, including those that can either be detected via more than one imaging technique (multi‐modal imaging agents) or used for both diagnosis and therapy (theranostics). A major obstacle to their medical application and translation to the clinic, however, is the fact that many accumulate in the liver and spleen as a result of opsonization and scavenging by the mononuclear phagocyte system. This focused review summarizes recent efforts to develop zwitterionic‐coatings to counter this issue and render nanoparticles more biocompatible. Such coatings have been found to greatly reduce the rate and/or extent of non‐specific adsorption of proteins and lipids to the nanoparticle surface, thereby inhibiting production of the “biomolecular corona” that is proposed to be a universal feature of nanoparticles within a biological environment. Additionally, in vivo studies have demonstrated that larger‐sized nanoparticles with a zwitterionic coating have extended circulatory lifetimes, while those with hydrodynamic diameters of ≤5 nm exhibit small‐molecule‐like pharmacokinetics, remaining sufficiently small to pass through the fenestrae and slit pores during glomerular filtration within the kidneys, and enabling efficient excretion via the urine. The larger particles represent ideal candidates for use as blood pool imaging agents, whilst the small ones provide a highly promising platform for the future development of theranostics with reduced side effect profiles and superior dose delivery and image contrast capabilities. 相似文献
86.
Dan A. Buzatu Willie M. Cooper Christine Summage-West John B. Sutherland Anna J. Williams Deborah A. Bass Lisa L. Smith Robert S. Woodruff Jessica M. Christman Steven Reid Randal K. Tucker Christopher J. Haney Ashfaqe Ahmed Fatemeh Rafii Jon G. Wilkes 《Food microbiology》2013
A flow cytometric method (RAPID-B™) with detection sensitivity of one viable cell of Escherichia coli serotype O157:H7 in fresh spinach (Spinacia oleracea) was developed and evaluated. The major impediment to achieving this performance was mistaking autofluorescing spinach particles for tagged target cells. Following a 5 h non-selective enrichment, artificially inoculated samples were photobleached, using phloxine B as a photosensitizer. Samples were centrifuged at high speed to concentrate target cells, then gradient centrifuged to separate them from matrix debris. In external laboratory experiments, RAPID-B and the reference method both correctly detected E. coli O157:H7 at inoculations of ca. 15 cells. In a follow-up study, after 4 cell inoculations of positives and 6 h enrichment, RAPID-B correctly identified 92% of 25 samples. The RAPID-B method limit of detection (LOD) was one cell in 25 g. It proved superior to the reference method (which incorporated real time-PCR, selective enrichment, and culture plating elements) in accuracy and speed. 相似文献
87.
Lisa Landrum 《Journal of Architectural Education》2013,67(2):284-286
88.
Lisa Meier-Dinkel Johanna Trautmann Luc Frieden Ernst Tholen Christoph Knorr Ahmad Reza Sharifi Mark Bücking Michael Wicke Daniel Mörlein 《Meat science》2013
This study aimed to assess the influence of two label conditions on the acceptance of boar meat. A central location test was conducted with 145 consumers each assessing 4 pieces of pork loin. 相似文献
89.
90.
Aguayo David; Herman Keith; Ojeda Lizette; Flores Lisa Y. 《Canadian Metallurgical Quarterly》2011,4(2):79
In hopes of promoting college success among Mexican Americans, researchers have identified factors related to their academic performance. A gap in the literature exists between the interactive role of acculturation, enculturation, and generation status in predicting college self-efficacy and college performance (grade-point average, or GPA). To fill this void, this study investigated the relation of demographic variables (e.g., age, gender, socioeconomic status) and cultural variables (e.g., acculturation, enculturation, generation status) on academic outcomes (e.g., college self-efficacy, college performance) among 408 Mexican-American college students. Results of a series of hierarchical regression analyses indicated socioeconomic status, generation status, enculturation, and acculturation had significant positive effects on college self-efficacy; socioeconomic status and the interaction of higher enculturation and first-generation status were positively and significantly related to GPA. Post-hoc analyses indicated college self-efficacy predicted college performance for students who were second generation and beyond. Implications for research and practice are discussed. (PsycINFO Database Record (c) 2011 APA, all rights reserved) 相似文献